反应详情

3-Hydroxy-5-methylisoxazole was reacted with benzoyl chloride in the presence of triethylamine to give 3-benzoyloxy-5-methylisoxazole, which was then reacted with N-bromosuccinimide, to give 3-benzoyloxy-5-bromomethylisoxazole. This was reacted with disodium thioglycolate to give 3-hydroxyisoxazol-5-ylmethylthioacetic acid, which was treated with diphenyldiazomethane to give the benzhydryl ester.