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0 °C

To a stirred solution of (5-amino-4-benzyl-3-n-butoxybenzyl)dimethylamine (6.25 g) in a mixture of concentrated hydrochloric acid (10 ml) and acetic acid (10 ml) a solution of sodium nitrite (1.4 g) in water (5 ml) is dropwise added during 30 minutes, keeping the temperature at 0°-3° C. by external cooling. After additional stirring at 0° C. for 10 minutes, the resulting diazonium-solution is slowly added to a solution or cupric chloride dihydrate (1.5 g) in water (4 ml) and acetic acid (25 ml) saturated with dry sulphur dioxide while stirring at 22°-25° C. After stirring for a further 1 hour, the mixture is cooled to precipitate crude (4-benzyl-3-n-butoxy-5-chlorosulfonylbenzyl)dimethylamine hydrochloride. The hydrochloride is collected by filtration and washed with a minor amount of ice-cold acetic acid. It is then added in portions to a stirred, saturated solution of dry ammonia in methanol (30 ml) keeping the temperature at 10°-12° C. by external cooling. The resulting solution is stirred for 16 hours at 22°-25° C. and is then diluted with water (100 ml) to precipitate crude (4-benzyl-3-n-butoxy-5-sulfamylbenzyl)dimethylamine. After filtration and recrystallization twice from aqueous ethanol it is obtained with a melting point of 109°-111° C. The material (IR, analysis) is identical with the material prepared as in Example 180.

1. additionis dropwise added during 30 minutes
2. customat 0°-3° C.
3. stirringwhile stirring at 22°-25° C
4. stirringAfter stirring for a further 1 hour
5. temperaturethe mixture is cooled
6. customto precipitate crude (4-benzyl-3-n-butoxy-5-chlorosulfonylbenzyl)dimethylamine hydrochloride
7. filtrationThe hydrochloride is collected by filtration
8. washwashed with a minor amount of ice-cold acetic acid
9. additionIt is then added in portions to a stirred, saturated solution of dry ammonia in methanol (30 ml)
10. customat 10°-12° C.
11. stirringThe resulting solution is stirred for 16 hours at 22°-25° C.
12. additionis then diluted with water (100 ml)
13. customto precipitate crude (4-benzyl-3-n-butoxy-5-sulfamylbenzyl)dimethylamine
14. filtrationAfter filtration and recrystallization twice from aqueous ethanol it
15. customis obtained with a melting point of 109°-111° C
16. customThe material (IR, analysis) is identical with the material prepared as in Example 180