反应详情

α-Carboxy(2,3-dihydro-5-benzofuranyl)acetic acid (10 mmole) is dissolved in 50 ml of water containing 10 mmole of sodium hydroxide. This mixture is stirred for 30 minutes at room temperature and then 10 mmole of chloromethylacetate in 25 ml of ether is added. The temperature during the addition is 10° C.; after the addition is complete, the temperature is raised to 20° C. and the mixture stirred for an additional 30 minutes. The pH is adjusted to 2 and ethyl acetate is added. The organic phase is removed, dried over magnesium sulfate, filtered and evaporated to give the title compound.

1. additionThe temperature during the addition
2. customis 10° C.
3. additionafter the addition
4. temperaturethe temperature is raised to 20° C.
5. stirringthe mixture stirred for an additional 30 minutes
6. additionis added
7. customThe organic phase is removed
8. dry with materialdried over magnesium sulfate
9. filtrationfiltered
10. customevaporated