反应详情

Heat 55 g. of the crude 5-(diphenylmethyl)-2-pyridone and 110 ml. of phenylphosphoric dichloride at 200°-210° with stirring for 6 hours. Pour the cooled reaction mixture onto ice, basify with ammonium hydroxide, extract with ethyl ether, dry the ether extracts, and concentrate to a residue. Distill the residue at 160°-175°/0.15 mm. and crystallize the distillate from hexane to obtain 2-chloro-5-(diphenylmethyl)-pyridine, m.p. 69.5°-71°.

1. temperatureHeat 55 g
2. additionPour
3. customthe cooled reaction mixture onto ice
4. extractionextract with ethyl ether
5. dry with materialdry the ether
6. concentrationconcentrate to a residue
7. distillationDistill the residue at 160°-175°/0.15 mm
8. customand crystallize the distillate from hexane