Chloroacetonitrile → HCID 22748760, compound

Participants

Reaction Conditions

Reaction Steps

Suspend 4.3 g. (0.015 mole) of 5-(diphenylmethyl)-picolinic acid in 100 ml. of acetone with stirring and add 2.3 g. (0.023 mole) of triethylamine. To the resulting solution add dropwise 1.7 g. (0.023 mole) of chloroacetonitrile. Stir the reaction mixture at room temperature (25° C.) for 15 minutes, then reflux for 4 hours. Cool and filter the reaction mixture. Concentrate the filtrate to a residue in vacuo and triturate the residue with hot isopropyl ether to yield the product of this example, yield 3.5 g., m.p. 95°-98° C.

Provenance & Evidence