Diethyl Ether → HCID 70605419, compound

HRID 1390335Notes

Reaction equation

HRID 1390335 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=2)[C:9]2[CH:10]=[CH:11][C:12]([C:15]([OH:17])=[O:16])=[N:13][CH:14]=2)=[CH:4][CH:3]=1.[NH:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1.CCOCC>CO>[NH:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1.[Cl:24][C:21]1[CH:20]=[CH:19][C:18]([CH:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)[C:9]2[CH:10]=[CH:11][C:12]([C:15]([OH:17])=[O:16])=[N:13][CH:14]=2)=[CH:23][CH:22]=1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 4837PiperazineHCID 22748770HCID 22748770, compound

Product 1

HCID 70605419HCID 70605419, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Combine 19.8 g. (0.055 mole) of 5-[bis-(4-chlorophenyl) methyl]-picolinic acid with 4.7 g. of piperazine in hot methanol. Add 5 volumes of ether and collect the precipitate by filtration. Recrystallize the precipitate from ethanol to obtain thereby the product of this example, m.p. 240°-255° C.

Workup

  1. customcollect the precipitate
  2. filtrationby filtration
  3. customRecrystallize the precipitate from ethanol
  4. customto obtain

Sources & evidence

ORD record
ord-48f286c97ca6433895964c847d9d58bf
Source dataset
uspto-grants-1979_02
Patent number
US04138488

Reaction notes

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