Potassium Hydroxide → HCID 22748753, compound

HRID 1390337Notes

Reaction equation

HRID 1390337 reaction equation
[C:1]1([C:7]([C:16]2[CH:21]=[CH:20][N:19]=[C:18]([C:22](N)=[O:23])[CH:17]=2)([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:8][CH3:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-:25].[K+]>C(O)C>[C:10]1([C:7]([C:16]2[CH:21]=[CH:20][N:19]=[C:18]([C:22]([OH:25])=[O:23])[CH:17]=2)([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:8][CH3:9])[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 22748755HCID 22748755, compound

Product 1

HCID 22748753HCID 22748753, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Dissolve 3.8 g. of 4-(1,1-diphenylpropyl)-picolinamide in 50 ml. of ethanol, add 100 ml. of 10% aqueous potassium hydroxide and heat the resulting mixture at reflux overnight. Remove the ethanol under reduced pressure, add water to the residue and adjust to about pH 5 with 10% aqueous hydrochloric acid. Filter the resulting solid and crystallize the precipitate from ethanol to obtain thereby the compound of this example, yield -- 1.6 g., m.p. 191°-193° C.

Workup

  1. dissolutionDissolve 3.8 g
  2. temperatureat reflux overnight
  3. customRemove the ethanol under reduced pressure
  4. additionadd water to the residue
  5. filtrationFilter the resulting solid
  6. customcrystallize the precipitate from ethanol
  7. customto obtain

Sources & evidence

ORD record
ord-1d9098e3765043c78791259408026c19
Source dataset
uspto-grants-1979_02
Patent number
US04138488

Reaction notes

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