Hydrochloric Acid → HCID 12682411, compound
Reaction equation
[CH3:1][CH:2]([P:11](=[O:18])([O:15][CH2:16][CH3:17])[O:12][CH2:13][CH3:14])[CH2:3][CH:4](OCC)[O:5]CC.Cl>O.CC(C)=O>[CH3:1][CH:2]([P:11](=[O:18])([O:15][CH2:16][CH3:17])[O:12][CH2:13][CH3:14])[CH2:3][CH:4]=[O:5]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 62 °C
Procedure
A solution of 400 grams (1.42 moles) of diethyl 1-methyl-3,3-diethoxypropylphosphonate in 1 liter of water and 4 liters of acetone containing 30 ml of concentrated hydrochloric acid was stirred and refluxed under nitrogen at 62° C. for 1.5 hours. Low boiling materials were removed at 80° C./16 mm to give the diethyl 1-methyl-3-oxopropylphosphonate in a 296 grams (quantitative) yield as a pale yellow liquid. The structure was confirmed by NMR.
Workup
- customwere removed at 80° C./16 mm
Sources & evidence
- ORD record
- ord-cee2aa3c85804153a4b4bb55a6b17747
- Source dataset
- uspto-grants-1979_02
- Patent number
- US04138569
Reaction notes
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