Hydrochloric Acid → HCID 20505858, compound

HRID 1390504Notes

Reaction equation

HRID 1390504 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([S:11]([N:14]2[CH2:19][CH2:18][CH:17]([CH2:20]Cl)[CH2:16][CH2:15]2)(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[OH-].[Na+].Cl>O>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([S:11]([N:14]2[CH2:19][CH2:18][C:17](=[CH2:20])[CH2:16][CH2:15]2)(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 205059532-Chloro-5-(4-chloromethylpiperidinosulfonyl)benzoic Acid

Product 1

HCID 20505858HCID 20505858, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-Chloro-5-(4-chloromethylpiperidinosulfonyl)benzoic acid (0.5 g.) is dissolved in 10 ml. of 5N sodium hydroxide and refluxed for one hour. 10 ml. of water is then added and the mixture is acidified with concentrated hydrochloric acid. The precipitated solid is chromatographed on a 10 g. silica gel column with a developing solvent system of 1:7 benzene:hexane containing 5% acetic acid. 2-Chloro-5-(4-methylenepiperidinosulfonyl)benzoic acid, m.p. 157°-160° C., is isolated from the first fraction.

Workup

  1. customThe precipitated solid is chromatographed on a 10 g

Sources & evidence

ORD record
ord-7ef9ff76caff47e89382fc05d53f6479
Source dataset
uspto-grants-1979_02
Patent number
US04138399

Reaction notes

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