1-Acetyl-2-phenylhydrazine → HCID 21332494, compound

HRID 1390519Notes

Reaction equation

HRID 1390519 reaction equation
[CH3:1][N:2]=[C:3]=[O:4].[C:5]([NH:8][NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(=[O:7])[CH3:6]>C(N(CC)CC)C.ClCCl>[C:5]([NH:8][N:9]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:3]([NH:2][CH3:1])=[O:4])(=[O:7])[CH3:6]

Participants

5

Reactant 2

HCID 82471-Acetyl-2-phenylhydrazineHCID 12228Methyl Isocyanate

Product 1

HCID 21332494HCID 21332494, compound

Reagents, catalysts & solvents 2

HCID 8471TriethylamineCatalystHCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Procedure

A 5.7-g (0.1-mol) sample of methyl isocyanate was added dropwise to a solution of 15.0 g (0.1 mol) 1-acetyl-2-phenyl-hydrazine and 2 drops triethylamine in 200 ml dichloromethane. The resulting reaction mixture was stirred for 2 hours at about 25° C., refluxed for about 16 hours and evaporated under reduced pressure to give 21 g of crude 1-acetyl-2-phenyl-4-methyl semicarbazide, as a yellow solid.

Workup

  1. customThe resulting reaction mixture
  2. temperaturerefluxed for about 16 hours
  3. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-7f823fd8c5e54291ad1edc2a75c03c27
Source dataset
uspto-grants-1979_02
Patent number
US04139363

Reaction notes

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