反应详情

A suspension of 1.0 gram of N2 -(7-methoxy-2-naphthalenesulfonyl)-L-arginine in 15 ml of anhydrous methanol was saturated with dry hydrogen chloride for one hour. The reaction mixture was refluxed for an additonal one hour. After cooling, the reaction mixture was concentrated in vacuo. The residue was triturated with cold ethyl ether to give a crystalline product. After crystallization from methanolethyl ether, N2 -(7-methoxy-2-naphthalenesulfonyl)-L-arginine methyl ester hydrochloride was obtained in 95% yield; mp. 115 - 118° C.

1. temperatureThe reaction mixture was refluxed for an additonal one hour
2. temperatureAfter cooling
3. concentrationthe reaction mixture was concentrated in vacuo
4. customThe residue was triturated with cold ethyl ether
5. customto give a crystalline product
6. customAfter crystallization from methanolethyl ether