Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 1-(3,5-Dichloro-4-methoxyphenyl)piperazine hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Bis(2-chloroethyl)amine hydrochloride | HCID 522769 | — |
| 반응물 | 3,5-Dichloro-4-methoxyaniline | HCID 13178651 | — |
| 용매 | 1-Butanol | HCID 263 | — |
| 생성물 | 1-(3,5-Dichloro-4-methoxyphenyl)piperazine hydrochloride | HCID 44717149 | 29.8% |
반응 단계
A mixture of 3,5-dichloro-4-methoxyaniline (16.0g) and bis-(2-chloroethyl)amine hydrochloride (14.77g) in n-butanol (100 ml) was stirred under reflux for 48 hr. Anhydrous potassium carbonate (11.45g) was added and the resulting mixture was stirred under reflux for a further 24 hr., then filtered hot. The solid which precipitated on cooling was crystallised from ethanol-ether to give 1-(3,5-dichloro-4-methoxyphenyl)piperazine hydrochloride (3.7g) m.p. 252°-255°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04139621 |
| 출처 데이터셋 | uspto-grants-1979_02 |
| ORD ID | ord-43761a5cadbb4e049c5a8b64a38dc3d6 |
| 출처 메모 | uspto-grants-1979_02 |