反应详情

A mixture of 3,5-dichloro-4-methoxyaniline (16.0g) and bis-(2-chloroethyl)amine hydrochloride (14.77g) in n-butanol (100 ml) was stirred under reflux for 48 hr. Anhydrous potassium carbonate (11.45g) was added and the resulting mixture was stirred under reflux for a further 24 hr., then filtered hot. The solid which precipitated on cooling was crystallised from ethanol-ether to give 1-(3,5-dichloro-4-methoxyphenyl)piperazine hydrochloride (3.7g) m.p. 252°-255°.

1. temperatureunder reflux for 48 hr
2. stirringthe resulting mixture was stirred
3. temperatureunder reflux for a further 24 hr
4. filtration, then filtered hot
5. customThe solid which precipitated
6. temperatureon cooling
7. customwas crystallised from ethanol-ether