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HRID1390734

反应详情

EQUATION

反应方程式

HRID 1390734 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])C(O)C(O)C(=O)[O-].[K+].[Na+]
HCID9855836

Potassium sodium tartarate

C4H4KNaO6

结构：[Al+3].[H-].[H-].[H-].[H-].[Li+]
HCID21226445

未命名化合物

结构：C[C@H]1CC(=O)CC2=CC[C@H]3[C@@H]4CC[C@H](O)[C@@]4(C)CC[C@@H]3[C@]21CO
HCID70604712

未命名化合物

PRODUCTS

生成物

1
结构：C[C@H]1C[C@H](O)CC2=CC[C@H]3[C@@H]4CC[C@H](O)[C@@]4(C)CC[C@@H]3[C@]21CO
HCID70605460

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

2 次

PROCEDURE

实验过程

A solution of 17β,19-dihydroxy-1α-methyl-5-androsten-3-one in tetrahydrofuran is added to a suspension of lithium aluminum hydride in tetrahydrofuran. After stirring overnight at room temperature an aqueous solution of sodium potassium tartrate is added until a readily filtered granular precipitate forms. This precipitate is removed by filtration and washed well with ether. The filtrate and ether washings are combined, washed with water, dried over magnesium sulfate and concentrated under vacuum. Crystallization of the residue yields 1α-methyl-5-androstene-3β,17β,19-triol.

WORKUP

后处理

  1. additionis added until a readily filtered granular precipitate forms
  2. customThis precipitate is removed by filtration
  3. washwashed well with ether
  4. washwashed with water
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated under vacuum
  7. customCrystallization of the residue