反应详情

To a solution of potassium t-butoxide in dimethylsulfoxide at 25° C. under nitrogen is added with stirring 19-hydroxy-1β-methyl-4-androstene-3,17-dione in dimethylsulfoxide. After 15 minutes the mixture is poured onto a cold aqueous ammonium chloride solution. The solid is rapidly filtered, washed well with water and dissolved in ether. The ether solution is again washed with water and dried over sodium sulfate. The ether is removed at room temperature to yield 19-hydroxy-1β-methyl-5-androstene-3,17-dione.

1. filtrationThe solid is rapidly filtered
2. washwashed well with water
3. dissolutiondissolved in ether
4. washThe ether solution is again washed with water
5. dry with materialdried over sodium sulfate
6. customThe ether is removed at room temperature