Ammonium Chloride → 19-Hydroxy-1beta-methyl-5-androstene-3,17-dione

Participants

Reaction Steps

To a solution of potassium t-butoxide in dimethylsulfoxide at 25° C. under nitrogen is added with stirring 19-hydroxy-1β-methyl-4-androstene-3,17-dione in dimethylsulfoxide. After 15 minutes the mixture is poured onto a cold aqueous ammonium chloride solution. The solid is rapidly filtered, washed well with water and dissolved in ether. The ether solution is again washed with water and dried over sodium sulfate. The ether is removed at room temperature to yield 19-hydroxy-1β-methyl-5-androstene-3,17-dione.

Provenance & Evidence