19-Hydroxy-1alpha,4alpha-dimethyl-5-androstene-3,17-dione → 4alpha-Methyl-5-androstene-3beta,17beta,19-triol

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Substituting 17β,19-dihydroxy-4α-methyl-5-androsten-3-one, 19-hydroxy-1α,4α-dimethyl-5-androstene-3,17-dione, 17β,19-dihydroxy-4α,7α-dimethyl-5-androsten-3-one, 4α-methyl-17β,19-di(2'-tetrahydropyranyloxy)-5-androsten-3-one and 1α,4α-dimethyl-19-(2'-tetrahydropyranyloxy)-5-androstene-3,17-dione for the 17β,19-dihydroxy-4α,6,17α-trimethyl-5-androsten-3-one above results in the formation of 4α-methyl-5-androstene-3β,17β,19-triol, 1α,4α-dimethyl-5-androstene-3β,17β,19-triol, 4α,7α-dimethyl-5-androstene-3β,17β,19-triol, 4α-methyl-17β,19-di(2'-tetrahydropyranyloxy)-5-androsten-3β-ol and 1α,4α-dimethyl-19-(2'-tetrahydroyranyloxy)-5-androstene-3β,17β-diol, respectively.

Provenance & Evidence