HRID1390768

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)[Si](C)(C)OC[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12

HCID10573974

未命名化合物

结构：C[C@H]1C[C@@H]2[C@H](CC[C@]3(C)C(=O)CC[C@@H]23)[C@@]2(CO)CCC(=O)C=C12

HCID70583925

未命名化合物

PRODUCTS

生成物

结构：C[C@H]1C[C@@H]2[C@H](CC[C@]3(C)C(=O)CC[C@@H]23)[C@@]2(CO[Si](C)(C)C(C)(C)C)CCC(=O)C=C12

HCID22803259

未命名化合物

结构：CC(=O)O.CC(C)(C)[Si](C)(C)OC1CC[C@@]2(CO)C(=CC[C@@H]3[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]32)C1

HCID131711428

未命名化合物

PROCEDURE

实验过程

Following essentially the same procedure and substituting 19-hydroxy-6α-methyl-4-androstene-3,17-dione and 3β,19-dihydroxy-5-androsten-17-one 19-acetate for the 19-hydroxy-4-androstene-3,17-dione above results in the preparation of 19-t-butyldimethylsiloxy-6α-methyl-4-androstene-3,17-dione and 3-t-butyldimethylsiloxy-19-hydroxy-5-androsten-17-one acetate, respectively.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7cd645e76005409d8f763e6cfa22a618
来源数据集: uspto-grants-1979_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04139617
来源说明: uspto-grants-1979_02

反应 SMILES

[OH:1][CH2:2][C@@:3]12[C@@H:20]3[C@H:11]([C@H:12]4[C@@:16]([CH2:18][CH2:19]3)([CH3:17])[C:15](=[O:21])[CH2:14][CH2:13]4)[CH2:10][C@H:9]([CH3:22])[C:8]1=[CH:7][C:6](=[O:23])[CH2:5][CH2:4]2.O(C[C@@]12[C@@H]3[C@H]([C@H]4[C@@:46](CC3)(C)[C:45](=[O:51])CC4)CCC1=CC(=O)CC2)[Si:25]([C:28]([CH3:31])([CH3:30])[CH3:29])([CH3:27])[CH3:26]>>[O:1]([CH2:2][C@@:3]12[C@@H:20]3[C@H:11]([C@H:12]4[C@@:16]([CH2:18][CH2:19]3)([CH3:17])[C:15](=[O:21])[CH2:14][CH2:13]4)[CH2:10][C@H:9]([CH3:22])[C:8]1=[CH:7][C:6](=[O:23])[CH2:5][CH2:4]2)[Si:25]([C:28]([CH3:31])([CH3:30])[CH3:29])([CH3:27])[CH3:26].[C:45]([OH:51])(=[O:1])[CH3:46].[O:23]([CH:6]1[CH2:7][CH2:8][C@@:3]2([CH2:2][OH:1])[C:4](=[CH:9][CH2:10][C@@H:11]3[C@@H:20]2[CH2:19][CH2:18][C@@:16]2([CH3:17])[C@H:12]3[CH2:13][CH2:14][C:15]2=[O:21])[CH2:5]1)[Si:25]([C:28]([CH3:31])([CH3:30])[CH3:29])([CH3:27])[CH3:26]