反应详情

A solution of 19-hydroxy-4-androstene-3,17-dione, triphenylchlorosilane and pyridine contained in 100 ml of benzene is refluxed for a period of 18 hours. The resulting suspension is filtered and concentrated in vacuo to a yellow oil. The oil is placed on a silica gel chromatographic column packed in chloroform which is further eluted with chloroform. The chloroform eluant is evaporated to dryness in vacuo and the residue is recrystallized from methanol to yield 19-triphenylsiloxy-4-androstene-3,17-dione.

1. temperatureis refluxed for a period of 18 hours
2. filtrationThe resulting suspension is filtered
3. concentrationconcentrated in vacuo to a yellow oil
4. washis further eluted with chloroform
5. customThe chloroform eluant is evaporated to dryness in vacuo
6. customthe residue is recrystallized from methanol