Potassium Carbonate → HCID 70605331, compound

HRID 1390789Notes

Reaction equation

HRID 1390789 reaction equation
[C:1]([O:4][C@H:5]1[CH2:10][CH2:9][C@H:8]2[C@H:11]3[C@H:25]([CH2:26][CH2:27][C@:6]12[CH3:7])[C@:19]1([CH2:20][O:21]C(=O)C)[C:14]([CH2:15][C@@H:16]([O:28][CH2:29][CH3:30])[CH2:17][CH2:18]1)=[CH:13][CH2:12]3)(=[O:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[C:1]([O:4][C@H:5]1[CH2:10][CH2:9][C@H:8]2[C@H:11]3[C@H:25]([CH2:26][CH2:27][C@:6]12[CH3:7])[C@:19]1([CH2:20][OH:21])[C:14]([CH2:15][C@@H:16]([O:28][CH2:29][CH3:30])[CH2:17][CH2:18]1)=[CH:13][CH2:12]3)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 86736330HCID 86736330, compound

Product 1

HCID 70605331HCID 70605331, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3β-Ethoxy-5-androstene-17β,19-diol diacetate is added to an aqueous methanol solution of potassium carbonate and the reaction solution stirred at room temperature for about 2 hours. The reaction mixture is poured onto water, and the oil which results is extracted into ether. The ether extract is washed with water, dried over magnesium sulfate and concentrated to dryness. Crystallization of the residue from an ether-pentane mixture yields 3β-ethoxy-5-androstene-17β,19-diol 17-acetate.

Workup

  1. additionThe reaction mixture is poured onto water
  2. customthe oil which results
  3. extractionis extracted into ether
  4. extractionThe ether extract
  5. washis washed with water
  6. dry with materialdried over magnesium sulfate
  7. concentrationconcentrated to dryness
  8. customCrystallization of the residue from an ether-pentane mixture

Sources & evidence

ORD record
ord-f74078a0cc58495790ea1fccafc1a9b3
Source dataset
uspto-grants-1979_02
Patent number
US04139617

Reaction notes

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