HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-2-phenylacetonitrile → 1-(4-Amino-2-methyl-5-phenyl-1H-pyrrol-3-yl)-1-propanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-2-phenylacetonitrile | HCID 40838 | — |
| Reactant | 2,4-Hexanedione | HCID 76355 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(4-Amino-2-methyl-5-phenyl-1H-pyrrol-3-yl)-1-propanone | HCID 20330040 | 53% |
Reaction Steps
Starting from 2-amino-2-phenylacetonitrile and hexane-2,4-dione, the open-chain intermediate compound is obtained, b.p. 160° C./0.3 mm Hg. The title compound is obtained in an overall yield of 53%, m.p. 166°-168° C. (from methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04140696 |
| Source dataset | uspto-grants-1979_02 |
| ORD ID | ord-3d02e3bd42d047699331365ec462c042 |
| Source note | uspto-grants-1979_02 |