Piperidine → HCID 12952393, compound

HRID 1390916Notes

Reaction equation

HRID 1390916 reaction equation
[C:1]([C:4]1[CH:5]=[CH:6][C:7](F)=[C:8]([S:10]([NH2:13])(=[O:12])=[O:11])[CH:9]=1)(=[O:3])[CH3:2].[NH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1>C(O)C>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([N:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[C:8]([S:10]([NH2:13])(=[O:12])=[O:11])[CH:9]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 8082PiperidineHCID 213316525-Acetyl-2-fluorobenzenesulphonamide

Product 1

HCID 12952393HCID 12952393, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 5-acetyl-2-fluorobenzenesulphonamide (1 g) and piperidine (0.98 g) in ethanol (50 ml) was heated under reflux for 3.5 hours. The solvent was removed and the residue was dissolved in ethyl acetate (100 ml) and washed with water (2 × 100 ml). The organic phase was dried (MgSO4) and concentrated and the product was crystallised from isopropanol, 0.92 g, m.p. 130.5°-131.5°.

Workup

  1. temperatureunder reflux for 3.5 hours
  2. customThe solvent was removed
  3. dissolutionthe residue was dissolved in ethyl acetate (100 ml)
  4. washwashed with water (2 × 100 ml)
  5. dry with materialThe organic phase was dried (MgSO4)
  6. concentrationconcentrated
  7. customthe product was crystallised from isopropanol, 0.92 g, m.p. 130.5°-131.5°

Sources & evidence

ORD record
ord-a81b984f3d604f279460726aa382ce70
Source dataset
uspto-grants-1979_02
Patent number
US04140713

Reaction notes

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