Diethylamine → HCID 12952396, compound

HRID 1390918Notes

Reaction equation

HRID 1390918 reaction equation
[C:1]([C:4]1[CH:5]=[CH:6][C:7](F)=[C:8]([S:10]([NH2:13])(=[O:12])=[O:11])[CH:9]=1)(=[O:3])[CH3:2].[CH2:15]([NH:17][CH2:18][CH3:19])[CH3:16]>C(O)C>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([N:17]([CH2:18][CH3:19])[CH2:15][CH3:16])=[C:8]([S:10]([NH2:13])(=[O:12])=[O:11])[CH:9]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 213316525-Acetyl-2-fluorobenzenesulphonamide

Product 1

HCID 12952396HCID 12952396, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 5-acetyl-2-fluorobenzenesulphonamide (6.5 g), diethylamine (7.0 ml) and absolute ethanol (200 ml) was heated under reflux for 22 hours. The solution was concentrated to a gum under reduced pressure and partitioned between ethyl acetate (100 ml) and water (120 ml). The organic phase was separated and evaporated to dryness. Trituration of the residue with aqueous isopropanol gave the diethylamine compound as cream crystals, 5.9 g, m.p. 103°-105°.

Workup

  1. temperatureunder reflux for 22 hours
  2. concentrationThe solution was concentrated to a gum under reduced pressure
  3. custompartitioned between ethyl acetate (100 ml) and water (120 ml)
  4. customThe organic phase was separated
  5. customevaporated to dryness

Sources & evidence

ORD record
ord-34654a32d2e8445ebf8943274b3877cb
Source dataset
uspto-grants-1979_02
Patent number
US04140713

Reaction notes

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