Ammonia → 5-Acetyl-2-aminobenzenesulfonamide

HRID 1390919Notes

Reaction equation

HRID 1390919 reaction equation
[C:1]([C:4]1[CH:5]=[CH:6][C:7](F)=[C:8]([S:10]([NH2:13])(=[O:12])=[O:11])[CH:9]=1)(=[O:3])[CH3:2].[NH3:15]>C(O)C>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([NH2:15])=[C:8]([S:10]([NH2:13])(=[O:12])=[O:11])[CH:9]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 213316525-Acetyl-2-fluorobenzenesulphonamide

Product 1

HCID 129523995-Acetyl-2-aminobenzenesulfonamide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A solution of 5-acetyl-2-fluorobenzenesulphonamide (0.5 g) in ethanol (40 ml) saturated with ammonia was heated at 100° in a bomb overnight. Concentration of the resultant solution yielded a yellow crystalline solid, 0.4 g, m.p. 263°-264° (from ethanol).

Sources & evidence

ORD record
ord-29fb6051b58f4d79a090e50d77968522
Source dataset
uspto-grants-1979_02
Patent number
US04140713

Reaction notes

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