4-Chloro-7-(trifluoromethyl)quinoline → 4-[[4-[[4-(p-Methylphenyl)-1-piperazinyl]methyl]phenyl]amino]-7-(trifluoromethyl)quinoline

HRID 1390979Notes

Reaction equation

HRID 1390979 reaction equation
[C:1]1([CH3:21])[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=3)[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.Cl[C:23]1[C:32]2[C:27](=[CH:28][C:29]([C:33]([F:36])([F:35])[F:34])=[CH:30][CH:31]=2)[N:26]=[CH:25][CH:24]=1>>[CH3:21][C:1]1[CH:2]=[CH:3][C:4]([N:7]2[CH2:8][CH2:9][N:10]([CH2:13][C:14]3[CH:19]=[CH:18][C:17]([NH:20][C:23]4[C:32]5[C:27](=[CH:28][C:29]([C:33]([F:36])([F:34])[F:35])=[CH:30][CH:31]=5)[N:26]=[CH:25][CH:24]=4)=[CH:16][CH:15]=3)[CH2:11][CH2:12]2)=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 676684-Chloro-7-(trifluoromethyl)quinolineHCID 213318441-(p-Tolyl)-4-[(4-aminophenyl)methyl]piperazine

Product 1

HCID 213318944-[[4-[[4-(p-Methylphenyl)-1-piperazinyl]methyl]phenyl]amino]-7-(trifluoromethyl)quinoline

Procedure

In the manner given in Example 1C, 1-(p-tolyl)-4-[(4-aminophenyl)methyl]piperazine and 4-chloro-7-(trifluoromethyl)quinoline are reacted together at reflux to give 4-[[4-[[4-(p-methylphenyl)-1-piperazinyl]methyl]phenyl]amino]-7-(trifluoromethyl)quinoline.

Workup

  1. customare reacted together
  2. temperatureat reflux

Sources & evidence

ORD record
ord-e173843549a348b1bdc2bebbb708a736
Source dataset
uspto-grants-1979_02
Patent number
US04140775

Reaction notes

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