HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-7-(trifluoromethyl)quinoline → 4-[[4-[[4-(p-Methylphenyl)-1-piperazinyl]methyl]phenyl]amino]-7-(trifluoromethyl)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-7-(trifluoromethyl)quinoline | HCID 67668 | — |
| Reactant | 1-(p-Tolyl)-4-[(4-aminophenyl)methyl]piperazine | HCID 21331844 | — |
| Product | 4-[[4-[[4-(p-Methylphenyl)-1-piperazinyl]methyl]phenyl]amino]-7-(trifluoromethyl)quinoline | HCID 21331894 | — |
Reaction Steps
In the manner given in Example 1C, 1-(p-tolyl)-4-[(4-aminophenyl)methyl]piperazine and 4-chloro-7-(trifluoromethyl)quinoline are reacted together at reflux to give 4-[[4-[[4-(p-methylphenyl)-1-piperazinyl]methyl]phenyl]amino]-7-(trifluoromethyl)quinoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04140775 |
| Source dataset | uspto-grants-1979_02 |
| ORD ID | ord-e173843549a348b1bdc2bebbb708a736 |
| Source note | uspto-grants-1979_02 |