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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1391001Generated: November 2, 2026

4-Nitrobenzyl chloride → 1-(3,5-Difluorophenyl)-4-(p-nitrobenzyl)piperazine

https://huagongshe.com/reaction/1391001

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Nitrobenzyl chlorideHCID 7482—
Reactant4-(3,5-Difluorophenyl)piperazine dihydrochlorideHCID 21331885—
SolventTriethylamineHCID 8471—
Product1-(3,5-Difluorophenyl)-4-(p-nitrobenzyl)piperazineHCID 21331860—

Reaction Steps

In the manner given in Example 1A, p-nitrobenzyl chloride is reacted with 4-(3,5-difluorophenyl)piperazine dihydrochloride in the presence of triethylamine to give 1-(3,5 -difluorophenyl)-4-(p-nitrobenzyl)piperazine

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04140775
Source datasetuspto-grants-1979_02
ORD IDord-57d994a799af4aa4ab785b1c20046312
Source noteuspto-grants-1979_02