4-Nitrobenzyl chloride → 1-(3,5-Difluorophenyl)-4-(p-nitrobenzyl)piperazine

HRID 1391001Notes

Reaction equation

HRID 1391001 reaction equation
[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8]Cl)=[CH:6][CH:5]=1)([O-:3])=[O:2].Cl.Cl.[F:14][C:15]1[CH:16]=[C:17]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[CH:18]=[C:19]([F:21])[CH:20]=1>C(N(CC)CC)C>[F:21][C:19]1[CH:18]=[C:17]([N:22]2[CH2:27][CH2:26][N:25]([CH2:8][C:7]3[CH:10]=[CH:11][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=3)[CH2:24][CH2:23]2)[CH:16]=[C:15]([F:14])[CH:20]=1

Participants

4

Reactant 2

HCID 74824-Nitrobenzyl chlorideHCID 213318854-(3,5-Difluorophenyl)piperazine dihydrochloride

Product 1

HCID 213318601-(3,5-Difluorophenyl)-4-(p-nitrobenzyl)piperazine

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

In the manner given in Example 1A, p-nitrobenzyl chloride is reacted with 4-(3,5-difluorophenyl)piperazine dihydrochloride in the presence of triethylamine to give 1-(3,5 -difluorophenyl)-4-(p-nitrobenzyl)piperazine

Sources & evidence

ORD record
ord-57d994a799af4aa4ab785b1c20046312
Source dataset
uspto-grants-1979_02
Patent number
US04140775

Reaction notes

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