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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1391002Generated: October 31, 2026

1-(3,5-Difluorophenyl)-4-(p-nitrobenzyl)piperazine → 1-(3,5-Difluorophenyl)-4-[(4-aminophenyl)methyl-]piperazine

https://huagongshe.com/reaction/1391002

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(3,5-Difluorophenyl)-4-(p-nitrobenzyl)piperazineHCID 21331860—
Catalysttitanium(III) trichlorideHCID 10313229—
Product1-(3,5-Difluorophenyl)-4-[(4-aminophenyl)methyl-]piperazineHCID 21331823—

Reaction Steps

In the manner given in Example 1B, 1-(3,5-difluorophenyl)-4-(p-nitrobenzyl)piperazine is reduced with aqueous titanium trichloride to give 1-(3,5-difluorophenyl)-4-[(4-aminophenyl)methyl-]piperazine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04140775
Source datasetuspto-grants-1979_02
ORD IDord-49ac441be5be4f849e097f0794f967c8
Source noteuspto-grants-1979_02