4,7-Dichloroquinoline → HCID 21331870, compound

HRID 1391019Notes

Reaction equation

HRID 1391019 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Cl[C:23]1[C:32]2[C:27](=[CH:28][C:29]([Cl:33])=[CH:30][CH:31]=2)[N:26]=[CH:25][CH:24]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:9][CH2:10][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([NH:21][C:23]4[C:32]5[C:27](=[CH:28][C:29]([Cl:33])=[CH:30][CH:31]=5)[N:26]=[CH:25][CH:24]=4)=[CH:17][CH:16]=3)[CH2:12][CH2:13]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 68664,7-DichloroquinolineHCID 13544863HCID 13544863, compound

Product 1

HCID 21331870HCID 21331870, compound

Procedure

In the manner given in Example 1C, 1-(p-fluorophenyl)-4-[(4-aminophenyl)methyl]piperazine and 4,7-dichloroquinoline are reacted together at reflux to give 4-[[4-[[4-(p-fluorophenyl)-1-piperazinyl]methyl]phenyl]amino]-7-chloroquinoline.

Workup

  1. customare reacted together
  2. temperatureat reflux

Sources & evidence

ORD record
ord-c54794fed8844ba3b840e62cd5393f6e
Source dataset
uspto-grants-1979_02
Patent number
US04140775

Reaction notes

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