Guanidine → N-Diaminomethylene-(trans-2,5-dimethylpyrrolidin-1-yl)-acetamide

HRID 1391033Notes

Reaction equation

[NH2:1][C:2]([NH2:4])=[NH:3].[CH3:5][C@H:6]1[CH2:10][CH2:9][C@H:8]([CH3:11])[N:7]1[CH2:12][C:13](OC)=[O:14]>>[NH2:3][C:2]([NH2:4])=[N:1][C:13](=[O:14])[CH2:12][N:7]1[C@@H:8]([CH3:11])[CH2:9][CH2:10][C@@H:6]1[CH3:5]

Participants

Reactant 2

HCID 3520Guanidine

HCID 86736355Methyl (trans-2,5-dimethylpyrrolidin-1-yl)acetate

Product 1

HCID 70606731N-Diaminomethylene-(trans-2,5-dimethylpyrrolidin-1-yl)-acetamide

Procedure

By a procedure analogous to Example 7, guanidine is reacted with methyl (trans-2,5-dimethyl-pyrrolidin-1-yl)acetate to yield the title compound.

Sources & evidence

ORD record: ord-37467a7a32f44674a838ad495bde07af
Source dataset: uspto-grants-1979_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04140793

Reaction notes

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