Acetic Acid → alpha,alpha'-Bis(cyclopentadienyl)-2,5-difluoro-paraxylene
Reaction equation
Cl[CH2:2][C:3]1[CH:8]=[C:7]([F:9])[C:6]([CH2:10]Cl)=[CH:5][C:4]=1[F:12].[C:13]1(C([O-])=O)[CH2:17][CH:16]=[CH:15][CH:14]=1.[Na+].[C:22](O)(=O)[CH3:23].O.O1C[CH2:30][CH2:29][CH2:28]1>C1C=CC=CC=1>[CH:23]1([CH2:2][C:3]2[CH:8]=[C:7]([F:9])[C:6]([CH2:10][CH:17]3[CH:16]=[CH:15][CH:14]=[CH:13]3)=[CH:5][C:4]=2[F:12])[CH:22]=[CH:30][CH:29]=[CH:28]1Participants
Conditions
- Temperature
- 20 °C
Procedure
In a 50 ml round flask, 0.615 g (2.91 mmols) of α,α'-dichloro-2,5-difluoro-para-xylene are treated under nitrogen at room temperature with 6.11 ml of a 1-n solution of sodium cyclopentadienate in tetrahydrofuran. The dichloride reacts at once and causes the temperature to rise by about 8° C. The dark violet solution is allowed to stand at room temperature for 1 hour. The solution is then slightly acidified with 0.3 ml of glacial acetic acid, the color changing to pale yellow. The batch is dissolved in 50 ml of benzene, the benzene solution agitated with 20 ml of water, the water is removed, and the benzene solution washed with 2 × 2 ml of saturated sodium chloride solution. The organic phase is dried with calcium chloride and concentrated under reduced pressure at 20° C. A pressure of 0.1 mm Hg and a temperature of 20° C. are maintained for 24 hours, and 0.638 g of a highly viscous brown resin obtained (81% of the theoretical yield).
Workup
- customto rise by about 8° C
- customthe water is removed
- washthe benzene solution washed with 2 × 2 ml of saturated sodium chloride solution
- dry with materialThe organic phase is dried with calcium chloride
- concentrationconcentrated under reduced pressure at 20° C
- custom0.638 g of a highly viscous brown resin obtained (81% of the
- customtheoretical yield)
Sources & evidence
- ORD record
- ord-440a968667f1472d9eec8a114bece852
- Source dataset
- uspto-grants-1979_02
- Patent number
- US04140843
Reaction notes
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