反应详情

温度

20 °C

A solution of p-toluenesulfonyl chloride (42.0 g., 0.22 mole) in pyridine (100 ml.) is cooled in an ice bath while 4-acetoxy-5-propoxy-1-pentanol (36.8 g., 0.193 mole) is added dropwise with stirring during 40 minutes. The ice bath is replaced by a cool (20° C.) water bath and stirring is continued for 2 hours. The mixture is then poured into 500 ml. of water. The oily product is taken up in ether, washed with 2N hydrochloric acid and water, and dried over sodium sulfate. The solvent is distilled in vacuo to leave the crude title compound as a yellow oil.

1. additionis added dropwise
2. stirringstirring
3. waitis continued for 2 hours
4. additionThe mixture is then poured into 500 ml
5. washwashed with 2N hydrochloric acid and water
6. dry with materialdried over sodium sulfate
7. distillationThe solvent is distilled in vacuo