Hydrochloric Acid → HCID 178458026, compound

HRID 1391211Notes

Reaction equation

HRID 1391211 reaction equation
[ClH:1].[NH:2]1[C:10]2[CH2:9][CH2:8][NH:7][CH2:6][C:5]=2[N:4]=[CH:3]1.[CH:11]([N:14]=[C:15]=[S:16])([CH3:13])[CH3:12].Cl>C(#N)C.C(O)C>[ClH:1].[CH:11]([NH:14][C:15]([N:7]1[CH2:8][CH2:9][C:10]2[NH:2][CH:3]=[N:4][C:5]=2[CH2:6]1)=[S:16])([CH3:13])[CH3:12]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 75263Isopropyl IsothiocyanateHCID 178478317HCID 178478317, compound

Product 1

HCID 178458026HCID 178458026, compoundYield 76.5%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 6342AcetonitrileSolvent

Procedure

A solution of 2 g of 4,5,6,7-tetrahydro-imidazo-[4,5-c]-pyridine hydrochloride and 2.5 g of isopropyl isothiocyanate in 20 ml of acetonitrile and 5 ml of ethanol is refluxed 8 h. Evaporation of the solvent leaves a residue that is treated with one equivalent of ethanolic hydrogen chloride. Evaporation of the solvent leaves a residue which is crystallized from acetone to give 2.5 g of 5-(N-isopropyl-thiocarbamoyl)-4,5,6,7-tetrahydro-imidazo-[4,5-c]-pyridine hydrochloride, m.p. 170°.

Workup

  1. customEvaporation of the solvent
  2. customleaves a residue that
  3. customEvaporation of the solvent
  4. customleaves a residue which
  5. customis crystallized from acetone

Sources & evidence

ORD record
ord-4815daf66df94b9788e1c0c789a8770d
Source dataset
uspto-grants-1979_02
Patent number
US04141899

Reaction notes

Loading…