Methyl isothiocyanate → HCID 21330758, compound

HRID 1391213Notes

Reaction equation

HRID 1391213 reaction equation
[C:1]1([CH:7]2[C:12]3[N:13]=[CH:14][NH:15][C:11]=3[CH2:10][CH2:9][NH:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:16][N:17]=[C:18]=[S:19]>O1CCOCC1>[C:1]1([CH:7]2[C:12]3[N:13]=[CH:14][NH:15][C:11]=3[CH2:10][CH2:9][N:8]2[C:18](=[S:19])[NH:17][CH3:16])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 11167Methyl isothiocyanateHCID 2564674-Phenyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine

Product 1

HCID 21330758HCID 21330758, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 3.5 g of 4-phenyl-4,5,6,7-tetrahydro-imidazo-[4,5-c]-pyridine (Farmaco, Ed. Sci., 1967, 22, 821) and 3.5 g of methyl isothiocyanate in 55 ml of dioxane is refluxed for 4 h. The solution is cooled and filtered: 3.6 g of 4-phenyl-5-(N-methyl-thiocarbamoyl)-4,5,6,7-tetrahydroimidazo-[4,5-c]-pyridine, m.p. 228°, are collected.

Workup

  1. temperatureThe solution is cooled
  2. filtrationfiltered
  3. custom3.6 g of 4-phenyl-5-(N-methyl-thiocarbamoyl)-4,5,6,7-tetrahydroimidazo-[4,5-c]-pyridine, m.p. 228°, are collected

Sources & evidence

ORD record
ord-3d4a4a3df46d499d817a2c46dcc94b5c
Source dataset
uspto-grants-1979_02
Patent number
US04141899

Reaction notes

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