Hydrogen Bromide → HCID 178464600, compound

HRID 1391218Notes

Reaction equation

HRID 1391218 reaction equation
[CH2:1]([CH:3]1[C:8]2[N:9]=[CH:10][NH:11][C:7]=2[CH2:6][CH2:5][NH:4]1)[CH3:2].[CH2:12]([NH:14][C:15](=[NH:18])SC)[CH3:13].Br>C(#N)C>[CH2:1]([CH:3]1[C:8]2[N:9]=[CH:10][NH:11][C:7]=2[CH2:6][CH2:5][N:4]1[C:15](=[NH:18])[NH:14][CH2:12][CH3:13])[CH3:2]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 233422924-Ethyl-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridineHCID 178464633HCID 178464633, compound

Product 1

HCID 178464600HCID 178464600, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 1.5 g of 4-ethyl-4,5,6,7-tetrahydro-imidazo-[4,5-c]-pyridine and 1.18 g of N-ethyl-S-methyl-isothiourea in 15 ml of acetonitrile is refluxed for 8 h. After evaporation to dryness the residue is treated with one equivalent of ethanolic hydrogen bromide. After cooling, 1.5 g of 4-ethyl-5-(N-ethyl-guanyl)-4,5,6,7-tetrahydro-imidazo-[4,5-c]-pyridine monohydrobromide, m.p. 275°, are collected.

Workup

  1. customAfter evaporation to dryness the residue
  2. temperatureAfter cooling
  3. custom1.5 g of 4-ethyl-5-(N-ethyl-guanyl)-4,5,6,7-tetrahydro-imidazo-[4,5-c]-pyridine monohydrobromide, m.p. 275°, are collected

Sources & evidence

ORD record
ord-e91751393a69446db4fba1c9bdf284d4
Source dataset
uspto-grants-1979_02
Patent number
US04141899

Reaction notes

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