反应详情

A solution of 1.51 g of 4-ethyl-4,5,6,7-tetrahydro-imidazo-[4,5-c]-pyridine and 2.28 g of methyl isocyanate in 20 ml of dry dioxane is refluxed for 1.5 h. The solution is cooled and filtered. The solid collected is dissolved in 30 ml of methanol and treated with 7 ml of 2N sodium hydroxide for 2 h at room temperature. After neutralization the solution is extracted with chloroform. Evaporation of the solvent leaves a residue that is taken up in ethyl acetate. 1.05 g of the title compound, m.p. 240°, are collected.

1. temperatureThe solution is cooled
2. filtrationfiltered
3. customThe solid collected
4. dissolutionis dissolved in 30 ml of methanol
5. additiontreated with 7 ml of 2N sodium hydroxide for 2 h at room temperature
6. extractionAfter neutralization the solution is extracted with chloroform
7. customEvaporation of the solvent
8. customleaves a residue that
9. custom1.05 g of the title compound, m.p. 240°, are collected