Cyclopropyl isothiocyanate → HCID 178528008, compound

HRID 1391223Notes

Reaction equation

HRID 1391223 reaction equation
[NH:1]1[C:9]2[CH2:8][CH2:7][NH:6][CH2:5][C:4]=2[N:3]=[CH:2]1.[CH:10]1([N:13]=[C:14]=[S:15])[CH2:12][CH2:11]1>C(#N)C>[CH:10]1([NH:13][C:14]([N:6]2[CH2:7][CH2:8][C:9]3[NH:1][CH:2]=[N:3][C:4]=3[CH2:5]2)=[S:15])[CH2:12][CH2:11]1

Participants

4

Reactant 2

HCID 92463Cyclopropyl isothiocyanateHCID 178420865HCID 178420865, compound

Product 1

HCID 178528008HCID 178528008, compoundYield 32%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 2.462 g of 4,5,6,7-tetrahydro-imidazo-[4,5-c]-pyridine and 2.97 g of cyclopropyl isothiocyanate in 20 ml of acetonitrile is refluxed for 7 h. After evaporation to dryness, the residue is chromatographed on silica gel (ethyl acetateethanol as eluant) to give 1.42 g of the pure title compound, m.p. 185°.

Workup

  1. customAfter evaporation to dryness
  2. customthe residue is chromatographed on silica gel (ethyl acetateethanol as eluant)

Sources & evidence

ORD record
ord-a06a98d06ed344f9b0b3206896cec06a
Source dataset
uspto-grants-1979_02
Patent number
US04141899

Reaction notes

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