Methyl isothiocyanate → HCID 21330771, compound

HRID 1391225Notes

Reaction equation

HRID 1391225 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]1[C:11]2[N:12]=[CH:13][NH:14][C:10]=2[CH2:9][CH2:8][NH:7]1.[CH3:15][N:16]=[C:17]=[S:18]>C(#N)C>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]1[C:11]2[N:12]=[CH:13][NH:14][C:10]=2[CH2:9][CH2:8][N:7]1[C:17](=[S:18])[NH:16][CH3:15]

Participants

4

Reactant 2

HCID 11167Methyl isothiocyanateHCID 21330731HCID 21330731, compound

Product 1

HCID 21330771HCID 21330771, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Operating as in Example 14, 12 g of 4-(2-furyl)-4,5,6,7-tetrahydro-imidazo-[4,5-c]-pyridine (oil) are obtained from 18.4 g of histamine dihydrochloride and 16.6 ml of furfural. A solution of 1.89 g of 4-(2-furyl)-4,5,6,7-tetrahydro-imidazo-[4,5-c]-pyridine and 1.1 g of methyl isothiocyanate in 20 ml of acetonitrile is refluxed for 5 h. The solution is cooled and filtered: 1.54 g of the title compound, m.p. 200°, are collected.

Workup

  1. temperatureThe solution is cooled
  2. filtrationfiltered
  3. custom1.54 g of the title compound, m.p. 200°, are collected

Sources & evidence

ORD record
ord-ebe17981e77248d0aaf4dbbfe7631dfa
Source dataset
uspto-grants-1979_02
Patent number
US04141899

Reaction notes

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