Methyl isothiocyanate → HCID 21330771, compound

Participants

Reaction Steps

Operating as in Example 14, 12 g of 4-(2-furyl)-4,5,6,7-tetrahydro-imidazo-[4,5-c]-pyridine (oil) are obtained from 18.4 g of histamine dihydrochloride and 16.6 ml of furfural. A solution of 1.89 g of 4-(2-furyl)-4,5,6,7-tetrahydro-imidazo-[4,5-c]-pyridine and 1.1 g of methyl isothiocyanate in 20 ml of acetonitrile is refluxed for 5 h. The solution is cooled and filtered: 1.54 g of the title compound, m.p. 200°, are collected.

Provenance & Evidence