Isopropyl Isothiocyanate → HCID 23342288, compound

HRID 1391226Notes

Reaction equation

HRID 1391226 reaction equation
[CH2:1]([N:3]1[C:7]2[CH:8]([CH2:12][CH3:13])[NH:9][CH2:10][CH2:11][C:6]=2[N:5]=[CH:4]1)[CH3:2].[CH:14]([N:17]=[C:18]=[S:19])([CH3:16])[CH3:15]>CC#N>[CH2:1]([N:3]1[C:7]2[CH:8]([CH2:12][CH3:13])[N:9]([C:18](=[S:19])[NH:17][CH:14]([CH3:16])[CH3:15])[CH2:10][CH2:11][C:6]=2[N:5]=[CH:4]1)[CH3:2]

Participants

4

Reactant 2

HCID 75263Isopropyl IsothiocyanateHCID 21330749HCID 21330749, compound

Product 1

HCID 23342288HCID 23342288, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 9.3 g of 3,4-diethyl-4,5,6,7-tetrahydro-imidazo-[4,5-c]-pyridine and 7.59 g of isopropyl isothiocyanate in 75 ml of anhydrous CH3CN is refluxed for 7.5 hours. The solution is allowed to stand overnight at -15° C., then is filtered. 5.59 g of the crude title compound are collected; m.p. 195° C. (recrystallized from CH3CN).

Workup

  1. filtrationis filtered
  2. custom5.59 g of the crude title compound are collected
  3. customm.p. 195° C. (recrystallized from CH3CN)

Sources & evidence

ORD record
ord-68425a3173ca4342a415f05cf6059307
Source dataset
uspto-grants-1979_02
Patent number
US04141899

Reaction notes

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