Sodium hydride → Methyl 3-(2,6-diethyl-2,3,6-trimethyl-4-piperidyloxy)crotonate
Reaction equation
[CH2:1]([C:3]1([CH3:14])[CH:8]([CH3:9])[CH:7]([OH:10])[CH2:6][C:5]([CH2:12][CH3:13])([CH3:11])[NH:4]1)[CH3:2].[H-].[Na+].[C:17]([O:22][CH3:23])(=[O:21])[C:18]#[C:19][CH3:20]>C1C=CC=CC=1>[CH2:1]([C:3]1([CH3:14])[CH:8]([CH3:9])[CH:7]([O:10]/[C:19](/[CH3:20])=[CH:18]\[C:17]([O:22][CH3:23])=[O:21])[CH2:6][C:5]([CH2:12][CH3:13])([CH3:11])[NH:4]1)[CH3:2]Participants
Procedure
To a solution of 3.0 g of 2,6-diethyl-2,3,6-trimethyl-4-piperidinol (Compound 1) in 30 ml of benzene was added, in small portions at room temperature, 0.72 g of 50% sodium hydride. The mixture was then stirred for 30 minutes at room temperature. A solution of 2.2 g of methyl tetrolate in 10 ml of benzene was then added dropwise, with ice-cooling, to the mixture and the whole mixture was stirred at room temperature for 64 hours. The mixture was then poured into ice water and extracted with ethyl acetate. The extract was washed with a saturated aqueous solution of sodium chloride and then dried over anhydrous sodium sulphate. After removing the solvent, the residue was distilled under reduced pressure, giving 3.4 g of Compound 97 as a pale yellow oil (bp 109°-111° C./0.15 mmHg).
Workup
- temperaturecooling, to the mixture
- stirringthe whole mixture was stirred at room temperature for 64 hours
- extractionextracted with ethyl acetate
- washThe extract was washed with a saturated aqueous solution of sodium chloride
- dry with materialdried over anhydrous sodium sulphate
- customAfter removing the solvent
- distillationthe residue was distilled under reduced pressure
Sources & evidence
- ORD record
- ord-d6fb53a788ec4f818550eb290a163bef
- Source dataset
- uspto-grants-1979_02
- Patent number
- US04141883
Reaction notes
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