1,3-Propanediamine → Drometrizole

Participants

Reaction Steps

To a 1000-ml. round-bottomed, three-neck flask fitted with a gas inlet tube, stirrer and reflux condenser is added 20.0 grams (0.08 mol) of 2-nitro-2'-hydroxy-5'-methylazobenzene (99.7% pure) dissolved in a solution of 200 ml of xylene. To this solution is added with stirring a mixture of 23.0 grams (0.32 mol) of 1,3-diaminopropane, 100 ml of water and 4 grams (0.02 mol) of cupric acetate. Carbon monoxide gas is then bubbled through the stirred reaction mixture for 15-20 hours with the temperature being maintained at 85°-90° C.

Provenance & Evidence