Dibromoacetyl chloride → HCID 21330776, compound

HRID 1391259Notes

Reaction equation

HRID 1391259 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][NH2:13])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[Cl:20])[C:6]=2[CH:21]=1.[Br:22][CH:23]([Br:27])[C:24](Cl)=O.C([O-])(=O)C.[Na+]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:24]([CH:23]([Br:27])[Br:22])=[N:13][N:12]=[C:10]3[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[Cl:20])[C:6]=2[CH:21]=1

Participants

4

Reactant 3

HCID 79184Dibromoacetyl chlorideHCID 517045Sodium AcetateHCID 21330784HCID 21330784, compound

Product 1

HCID 21330776HCID 21330776, compound

Procedure

In the manner given in Example 2, 7-fluoro-5-(o-chlorophenyl)-3H-1,4-benzodiazepin-2-yl hydrazine was reacted with dibromoacetyl chloride and after 1.5 hours with sodium acetate, then the mixture was refluxed to give 8-fluoro-1-(dibromomethyl)-6-(o-chlorophenyl)-4H-s-triazolo-[4,3-a][1,4]benzodiazepine.

Workup

  1. temperaturethe mixture was refluxed

Sources & evidence

ORD record
ord-16bbf28ec13e4be1a6c13e3aeaa386ac
Source dataset
uspto-grants-1979_02
Patent number
US04141902

Reaction notes

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