Dichloroacetyl chloride → HCID 21330782, compound

HRID 1391264Notes

Reaction equation

HRID 1391264 reaction equation
[F:1][C:2]([F:32])([F:31])[C:3]1[C:8]2[C:9]([C:16]3[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH3:24])=[CH:18][CH:17]=3)=[N:10][CH2:11][C:12]([NH:14][NH2:15])=[N:13][C:7]=2[CH:6]=[C:5]([S:25]([CH2:28][CH2:29][CH3:30])(=[O:27])=[O:26])[CH:4]=1.[Cl:33][CH:34]([Cl:38])[C:35](Cl)=O.C([O-])(=O)C.[Na+]>>[Cl:33][CH:34]([Cl:38])[C:35]1[N:13]2[C:7]3[CH:6]=[C:5]([S:25]([CH2:28][CH2:29][CH3:30])(=[O:26])=[O:27])[CH:4]=[C:3]([C:2]([F:31])([F:1])[F:32])[C:8]=3[C:9]([C:16]3[CH:17]=[CH:18][C:19]([O:22][CH2:23][CH3:24])=[CH:20][CH:21]=3)=[N:10][CH2:11][C:12]2=[N:14][N:15]=1

Participants

4

Reactant 3

HCID 6593Dichloroacetyl chlorideHCID 517045Sodium AcetateHCID 21330777HCID 21330777, compound

Product 1

HCID 21330782HCID 21330782, compound

Procedure

In the manner given in Example 1, 6-trifluoromethyl-8-propylsulfonyl-5-(p-ethoxyphenyl)-3H-1,4-benzodiazepin-2-yl hydrazine was reacted with dichloroacetyl chloride and after 1.5 hours with sodium acetate, then refluxed to give 1-(dichloromethyl)-7-trifluoromethyl-9-propylsulfonyl-6-(p-ethoxyphenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Workup

  1. temperaturerefluxed

Sources & evidence

ORD record
ord-9ac280d6e8f041b5811f0291d403f99b
Source dataset
uspto-grants-1979_02
Patent number
US04141902

Reaction notes

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