Hydrogen Peroxide → HCID 178513670, compound

HRID 1391302Notes

Reaction equation

HRID 1391302 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][N:3]=1.[OH:11]O>C(O)(=O)C>[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][N+:3]=1[O-:11]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 95006-Aminonicotinamide

Product 1

HCID 178513670HCID 178513670, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
100 °C

Procedure

6-Aminonicotinamide, 50 g, was dissolved in warm glacial acetic acid, 500 ml. To this clear solution 30% hydrogen peroxide, 80 ml was slowly added with agitation. The mixture was then heated to 100° C. for 5 hours. The light brownish solution thus formed was evaporated to a syrupy residue which crystallized on cooling in an ice water bath. The crystals were washed with acetone and dried. The yield of practically pure 6-aminonicotinamide-1-oxide was 51.6 g. This product had a mobility (Rf) of 0.48 on thin-layer chromatogram using a solvent system of benzene:methanol, 1:1.

Workup

  1. customThe light brownish solution thus formed
  2. customwas evaporated to a syrupy residue which
  3. customcrystallized
  4. temperatureon cooling in an ice water bath
  5. washThe crystals were washed with acetone
  6. customdried

Sources & evidence

ORD record
ord-742f6226183842edbb49167c203bc23b
Source dataset
uspto-grants-1979_02
Patent number
US04141977

Reaction notes

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