反应详情

温度

100 °C

6-Aminonicotinamide, 50 g, was dissolved in warm glacial acetic acid, 500 ml. To this clear solution 30% hydrogen peroxide, 80 ml was slowly added with agitation. The mixture was then heated to 100° C. for 5 hours. The light brownish solution thus formed was evaporated to a syrupy residue which crystallized on cooling in an ice water bath. The crystals were washed with acetone and dried. The yield of practically pure 6-aminonicotinamide-1-oxide was 51.6 g. This product had a mobility (Rf) of 0.48 on thin-layer chromatogram using a solvent system of benzene:methanol, 1:1.

1. customThe light brownish solution thus formed
2. customwas evaporated to a syrupy residue which
3. customcrystallized
4. temperatureon cooling in an ice water bath
5. washThe crystals were washed with acetone
6. customdried