反应详情

To a solution of 119 g (0.816 mole) of 5-methyl-3-phenylbenzofuran in 1 l. of chloroform at 20° to 25° C. is added 143.5 g (0.895 mole) of bromine. The mixture is evaporated under vacuum and the residue is dissolved in diethyl ether. The ether solution is washed with water, 10% sodium bicarbonate solution and saturated sodium chloride solution. The dried mixture is filtered and the filtrate is evaporated under vacuum. The residue is suspended in hot petroleum ether, then the mixture is cooled to provide solid 2-bromo-5-methyl-3-phenylbenzofuran, m.p. 52°-57° C.

1. customThe mixture is evaporated under vacuum
2. dissolutionthe residue is dissolved in diethyl ether
3. washThe ether solution is washed with water, 10% sodium bicarbonate solution and saturated sodium chloride solution
4. filtrationThe dried mixture is filtered
5. customthe filtrate is evaporated under vacuum
6. temperaturethe mixture is cooled