Sodium Hydroxide → 2-(4-Chlorobenzoyl)-4-ethylphenyl benzoate

HRID 1391336ノート

反応式

HRID 1391336 の反応式
[OH:1][C:2]1[CH:16]=[CH:15][C:14]([CH2:17][CH3:18])=[CH:13][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1)=[O:5].[OH-:19].[Na+]>O.C(Cl)(=O)C1C=CC=CC=1>[C:4]([O:1][C:2]1[CH:16]=[CH:15][C:14]([CH2:17][CH3:18])=[CH:13][C:3]=1[C:4]([C:6]1[CH:7]=[CH:8][C:9]([Cl:12])=[CH:10][CH:11]=1)=[O:5])(=[O:19])[C:3]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:2]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 12562655(4-Chlorophenyl)(5-ethyl-2-hydroxyphenyl)methanone

生成物 1

HCID 138387532-(4-Chlorobenzoyl)-4-ethylphenyl benzoate

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 7412Benzoyl chloride溶媒

実験手順

2-Hydroxy-5-ethyl-4'-chlorobenzophenone (5 g, 0.019 mole) was stirred vigorously in a solution of NaOH (7.5 g, 0.187 mole) in water (75 ml) and benzoyl chloride was added dropwise over 5 minutes. The temperature rose to around 50° C. The mixture was stirred for 1.5 hours at room temperature and was then extracted with ether, the ether washed with saturated NaCl solution, dried (Na2SO4), filtered and evaporated to leave the product, which was recrystallised from n-hexane to give white crystals of the desired product, m.p. 79°-81° C.

後処理

  1. additionwas added dropwise over 5 minutes
  2. customrose to around 50° C
  3. extractionwas then extracted with ether
  4. washthe ether washed with saturated NaCl solution
  5. dry with materialdried (Na2SO4)
  6. filtrationfiltered
  7. customevaporated
  8. customto leave the product, which
  9. customwas recrystallised from n-hexane

出典と根拠

ORDレコード
ord-c2d89b93526145c59cc06c92f07d122e
出典データセット
uspto-grants-1979_02
特許番号
US04141995

反応ノート

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