Acetic Acid → 2-(4-Chlorobenzoyl)-4-ethylphenyl acetate

HRID 1391337ノート

反応式

HRID 1391337 の反応式
[OH:1][C:2]1[CH:16]=[CH:15][C:14]([CH2:17][CH3:18])=[CH:13][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1)=[O:5].[C:19](O)(=[O:21])[CH3:20].[OH-].[Na+]>C(OC(=O)C)(=O)C>[C:19]([O:1][C:2]1[CH:16]=[CH:15][C:14]([CH2:17][CH3:18])=[CH:13][C:3]=1[C:4]([C:6]1[CH:7]=[CH:8][C:9]([Cl:12])=[CH:10][CH:11]=1)=[O:5])(=[O:21])[CH3:20]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 14798Sodium HydroxideHCID 12562655(4-Chlorophenyl)(5-ethyl-2-hydroxyphenyl)methanone

生成物 1

HCID 138387542-(4-Chlorobenzoyl)-4-ethylphenyl acetate

試薬・触媒・溶媒 1

HCID 7918Acetic Anhydride溶媒

実験手順

2-Hydroxy-5-ethyl-4'-chlorobenzophenone (3 g), in acetic anhydride (10 ml) and acetic acid (1 ml) were refluxed for 3.5 hours, and allowed to cool. The mixture was poured into dilute NaOH solution and extracted with chloroform. The chloroform was washed with 10% NaHCO3 solution (50 ml), dried (MgSO4) and evaporated to leave an oil which was distilled, b.p. 160°-165° C. at 3.5 mm/Hg (2.3 g) to give the desired product.

後処理

  1. temperatureto cool
  2. extractionextracted with chloroform
  3. washThe chloroform was washed with 10% NaHCO3 solution (50 ml)
  4. dry with materialdried (MgSO4)
  5. customevaporated
  6. customto leave an oil which
  7. distillationwas distilled

出典と根拠

ORDレコード
ord-a38aa1267af449da881a180d0e5eb1f1
出典データセット
uspto-grants-1979_02
特許番号
US04141995

反応ノート

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