反应详情

Imidazo[1,5-a]pyridine (3.9 g.) in 100 ml. of dry acetonitrile is treated with 6.8 g of α-bromotoluene, and the resulting reaction mixture heated under reflux for 3 hrs. The solution is cooled and diluted with 250 ml. of diethyl ether. The resulting precipitate is filtered and recrystallized from isopropanol-diethyl ether, 7.92 g., m.p. 172°-176° C.

1. customthe resulting reaction mixture
2. temperatureheated
3. temperatureunder reflux for 3 hrs
4. temperatureThe solution is cooled
5. additiondiluted with 250 ml
6. filtrationThe resulting precipitate is filtered
7. customrecrystallized from isopropanol-diethyl ether, 7.92 g